Author

Markus Sauer

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Open access Sep 2026

Sphingolipids associate with the chlamydial nucleoid and mark developmental transitions in Chlamydia trachomatis

Chlamydia trachomatis is an obligate intracellular bacterial pathogen and a leading cause of sexually transmitted infections worldwide. During its biphasic developmental cycle, infectious, non-replicative elementary bodies alternate with replicative reticulate bodies within a membrane-bound intracellular niche known as...

Marcel Rühling, F. Wagner, Till Epprecht et al. · Nature Communications · 0 citations

Open access Aug 2026

Towards improved particle reconstruction for single-molecule localization microscopy using geometric deep learning

Abstract Motivation Single-molecule localization microscopy (SMLM) can resolve intracellular structures down to the nanoscale, but often produces sparse and incomplete data. Particle averaging (PA) can aid with the reconstruction of complete structures, but traditional PA methods can suffer from template bias or the hi...

Diana Mindroc-Filimon, Dominic A. Helmerich, P. Salome et al. · Bioinformatics Advances · 0 citations

Open access Jul 2026

RBM20 variants disrupt Ca2+ handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models

Mutations in the splice-regulator RBM20 cause heart failure with reduced ejection fraction (HFrEF), typically manifesting as dilated cardiomyopathy (DCM). Mutations at position 634 in the RS-domain cause DCM with (R634L) or without (R634W) left ventricular non-compaction (LVNC). However, the mechanisms underlying pheno...

S. Rebs, F. Sedaghat-Hamedani, E. Kayvanpour et al. · Signal Transduction and Targ... · 0 citations