Markus M. Rinschen

Beyond waste: arginine metabolism and ammonium detoxification in cardiovascular-renal-metabolic disease.

Ammonium is a toxic product of amino acid degradation and protein turnover that is incorporated into arginine and detoxified via the urea cycle. Recent work has expanded the role of ammonium detoxification and the urea cycle toward broader metabolic functions. This review examines how ammonium and urea cycle-related me...