Author

Mark McNeil

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#protein folding Open access Oct 2026

A modular constitutive single-plasmid platform for efficient production of a recombinant Strep A glycoconjugate vaccine

Production of glycoconjugate vaccines has long relied upon chemical methods which are highly complex and expensive, resulting in vaccines that are not widely affordable. Heterologous bioconjugation methods, such as Protein-Glycan Coupling Technology (PGCT), have emerged as a path to significantly cheaper manufactur...

Mark A. Harrison, Tom L. Flood, Mark Reglinski et al. · Communications Biology · 0 citations

Open access Aug 2026

Enterococcal Polysaccharide Antigen (EPA) rhamnan backbone contributes to cell wall architecture and is essential for antimicrobial resistance, innate immune evasion and phage infection

Enterococci are opportunistic pathogens classified by the World Health Organization as high-priority microorganisms. They cause a broad spectrum of infections, and their intrinsic and acquired resistance to antimicrobials makes these infections particularly difficult to treat and eradicate. In Enterococcus faecalis, th...

Lea Kupcova, Nishan Nathoo, B. Michno et al. · bioRxiv · 0 citations