Open access
Aug 2026
In vivo genome editing of central nervous system SIV reservoirs in ART-suppressed rhesus macaques
It is demonstrated that intact and potentially replication-competent virus persists in the primate brain under ART and that systemic AAV9-CRISPR can reach and edit proviral DNA in this sanctuary, supporting genome editing as a strategy toward durable remission of CNS reservoirs.
Hong Liu, Shu-Ren Liao, Chen Chen et al.
· Molecular Therapy: Nucleic A... · 1 citation