Author

Mark Chandy

2 papers indexed here

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Review Open access Aug 2026

Genetic associations in sepsis and ARDS

Critical illness syndromes, such as sepsis and acute respiratory distress syndrome (ARDS), are characterized by substantial clinical heterogeneity and remain major causes of morbidity and mortality worldwide. Increasing evidence suggests that genetic variation contributes to susceptibility, disease severity, and clinic...

Jonathan J. Moroniti, Poorna Manappurathu Rameshchandran, Meng-Qi Guo et al. · Frontiers in Pharmacology · 0 citations

Sep 2026

Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy.

Cardiac fibrosis independently predicts adverse outcomes in heart failure (HF), yet no Food and Drug Administration-approved therapy directly targets fibrotic remodeling in the heart. To address this unmet clinical need, we used a multidimensional drug discovery pipeline centered on a human induced pluripotent stem cel...

Hao Zhang, Rabindra V. Shivnaraine, Lu Ren et al. · Science · 0 citations