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Author

Mark Cannon

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Review Open access Aug 2026

The Oral and Nasal Gateway Microbiomes: Salivaomics and Systemic Health at the Airway–Digestive Interface

Simple Summary The oral and nasal microbiomes can be understood as a gateway ecosystem because the oral cavity connects the upper digestive tract and the upper airway. Diet, saliva, oxygen tension, breathing route, host immunity, and microbial ecology meet at this interface. This narrative review examines bacteria, fun...

Mark L. Cannon, John Peldyak, Paul R. Reynolds et al. · 0 citations
Review Open access Oct 2026

A Synbiotic for the Oral–Nasal Gateway: The Mechanistic Rationale, Pathogen-Targeting Profile, and Implications for Gut and Pulmonary Health

The oral cavity and the nasal passage form a single, continuously mixed ecological gateway rather than two independent niches: saliva is swallowed roughly once every one to two minutes while awake, and nasal mucus is transported posteriorly into the nasopharynx on a cycle of roughly ten to twenty minutes, so oral and n...

John Peldyak, Paul R. Reynolds, César Ulises Alas Pineda et al. · 0 citations
Review Open access Oct 2026

The Oral–Gut Microbiome Axis: Microbial Transit, Ectopic Colonization, Systemic Associations, Salivaomics, and Clinical Control Points

A narrative review summarizes microbial transit, key taxa, salivaomics, systemic associations, and practical oral control points and identifies clinical control points, including probiotics and polyols such as xylitol, as selective microbiome-modulating adjuncts at varying stages of evidence.

Mark L. Cannon, John Peldyak, David J. Vigerust · 0 citations

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