Mark C. Wilkinson

Disintegrin-like and Cysteine-rich Domains Govern Enzymatic Activity and Substrate Recognition in Echis Snake Venom Metalloproteinases

These findings establish accessory-domain-mediated substrate recognition as a key determinant of SVMP function, informing rational antivenom design and support a model in which PIII SVMP accessory domains enhance substrate positioning and catalytic efficiency while selectively restricting access to non-cognate substrates.