Author

Mario Morales Martinez

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Oct 2026

Abstract A055: Addressing disparate outcomes in triple negative breast cancer: Targeting metabolic and cell-cycle vulnerabilities with novel biguanide-mediated combination therapy

Triple-negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Despite constituting 12.7% of breast cancer (BC) cases, TNBC comprises 40% of BC mortalities with a three-fold increase in ea...

Julie Liu, Mario Morales Martinez, Eduardo Mauricio Gonzalez et al. · Cancer Epidemiology, Biomark... · 0 citations

Jul 2026

Abstract A077: Multi-pathway inhibition and synergistic anticancer activity of novel biguanides in triple negative breast cancer models

A novel treatment based on the biguanide metformin structure, termed JD006, which significantly inhibits TNBC cell growth in vitro and in vivo in a dose-dependent manner and at lower doses than its parental metformin, provides a strong preclinical rationale for combining next-generation biguanides with CDK4/6 inhibitor...

Julie Liu, Mario Morales Martinez, Eduardo Mauricio Gonzalez et al. · Clinical Cancer Research · 0 citations