Polymorphism of Prion Protein Gene and Evaluation on Genetic Risk for Scrapie in Three Native and One Introduced Breed in the Republic of North Macedonia
Abstract Transmissible spongiform encephalopathy in sheep is known as scrapie. Polymorphisms at codons 136, 154, and 171 of the prion protein (PRNP) gene are associated with resistance or susceptibility to the disease. Based on allele combinations, sheep are classified into five genetic risk groups. The aim of this stu...