Review
Open access
Sep 2026
The evolving epidemiology of opioid use disorder: polysubstance use, drug supply transformation, and policy implications
Background Synthetic Opioids and the rising polysubstance use have caused a substantial change in the epidemiology of opioid use disorder (OUD) in the United States. Current overdose patterns may no longer be adequately explained by traditional opioid-driven theories. Methods A structured review was conducted using PRI...
Naga Koushik Mandapati, D. Tovar, Riya Bindlish et al.
· Frontiers in Public Health · 0 citations