Open access
Sep 2026
Astrocyte Senescence Disrupts the Extracellular Mitochondrial Compartment and Compromises Bioenergetic Support to Human Neurons
Astrocyte senescence is a recognized feature of brain aging, but its impact on neuronal mitochondrial homeostasis remains poorly defined, particularly in human cells. Here we show that doxorubicin-induced senescence disrupts mitochondrial function in primary human astrocytes and compromises their capacity to sustain ne...
Pedro Amorim, Lívia de Sá Hayashide, Vitor Emanuel Leocadio et al.
· Antioxidants · 0 citations