Mariagiovanna Ballato

Association Between Biopsy PD-L1 Combined Positive Score and Pathological Upgrading at Radical Prostatectomy in Grade Group 1 Prostate Cancer: A Retrospective Study

Programmed death-ligand 1 (PD-L1) expression in Grade Group 1 (GG1) prostate carcinoma biopsies has not been established as a marker of pathological upgrading at radical prostatectomy (RP). This two-center retrospective case–control study included 172 men with GG1 carcinoma in the biopsy closest to RP: all 86 patients...

Aptamer-guided delivery of miR-126 suppresses glioblastoma stem-like cell invasion and tumor progression

Glioblastoma, IDH-wildtype (GBM) is the most common and aggressive primary brain tumor in adults, with a median overall survival of 15–18 months. New therapeutic targets are needed to improve patients’ prognosis. Due to their powerful regulatory capabilities, miRNAs could be possible candidate targets. MiR-126 is consi...

REVIEW The role of leptin in osteoarthritis: from pathogenesis to clinical implications

Detection of FGFR Alterations in Urothelial Carcinoma: Current Diagnostic Methodologies, Technical Considerations and Future Perspectives.

Conventional techniques, including DNA- and RNA-based next-generation sequencing, PCR-based companion diagnostic assays, fluorescence in situ hybridization, and immunohistochemistry are critically discussed together with emerging liquid biopsy strategies for longitudinal disease monitoring and resistance assessment.