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Author

Maria Santina Ler

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Book Open access Oct 2026

An Exploratory Multimodal Analysis of Digital Handwriting and Spontaneous Speech Features to Distinguish Early Cognitive Impairment from Normal Aging

Early screening for mild cognitive impairment (MCI) is crucial for managing neurodegenerative progression. This study explores the discriminatory power of two non-invasive digital biomarkers for cognitive decline detection: linguistics metrics extracted from spontaneous speech (via OpenAI Whisper) and spatio-temporal f...

Maria Santina Ler, Maria Sarno, Miriam Veneziano et al. · 0 citations
Review Open access 2026

Handwriting Analysis in Early Dementia Screening: Experimental Design and Diagnostic Potential—A Comprehensive Review

Traditional clinical assessments for Mild Cognitive Impairment (MCI) and dementia are time-consuming and often lack the sensitivity required to detect early cognitive decline. Digitized handwriting and drawing have emerged as promising behavioral biomarkers, yet their clinical translation remains limited by fragmented...

Maria Santina Ler, G. Cordasco, Antonio Perna et al. · 0 citations

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