PURPOSE
Claudin 18.2 (CLDN18.2), a tight junction protein normally expressed in gastric epithelium and rendered accessible during malignant transformation, has emerged as a key therapeutic target. Here, we seek to characterize the immune microenvironment of CLDN18.2-expressing gastric cancer and identify immune feature...
Joseph J. Zhao, Choong-kun Lee, Allison S. Y. Chan et al.· Clinical Cancer Research· 0 citations
Abstract Discrete stochastic processes are widespread across physics, chemistry, ecology, and beyond. In computational biology and epidemiology, however, most simulators still assume Markovian kinetics with memoryless dynamics, despite growing evidence for history-dependent effects in gene regulation, RNA transcription...
A. Pélissier, Miroslav Phan, N. Beerenwinkel et al.· Briefings in Bioinformatics· 0 citations
The AIntibody challenge shows that AI can optimize antibodies in defined, biologically grounded regimes, in addition to highlighting critical gaps including affinity prediction and library-inspired antibody design and cross-task generalization.
M. Erasmus, Daniel Bedinger, Elizabeth Hopkins et al.· Nature Biotechnology· 0 citations
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