Open access
Aug 2026
Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma
DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations1, 2, 3, 4–5. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long-term changes in chromatin configurat...
A. Modrek, K. Chandradoss, Catherine Do et al.
· Nature Communications · 0 citations