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Author

Maria Kirpichenko

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Oct 2026

D90N and D90K mutations in the chaperonin OBP reduce its ability to induce fibrillation of the prion protein by decreasing ATPase activity.

We have previously shown that, in the presence of ATP, phage chaperonins stimulate amyloid transformation of the prion protein and alpha-synuclein, while in the absence of ATP they prevent fibrillation of amyloidogenic proteins. To confirm the involvement of chaperonins in the transformation of amyloidogenic proteins i...

D. Pozdyshev, Victor N. Orlov, Maria Kirpichenko et al. · 0 citations

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