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Author

Maria Hondele

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Open access Oct 2026

Sequential Design of Experiments enables accessible and efficient multidimensional mapping of single- and multi-protein condensates

Biomolecular condensation emerges from networks of multivalent interactions that respond collectively to molecular composition and environmental conditions. Here, we establish a sequential Design of Experiments (DoE) framework to systematically and efficiently characterise multidimensional condensation landscapes. Appl...

Matej Siketanc, Ferdinand Weidner, Casimir Nüsperling et al. · 0 citations
Open access Sep 2026

A bacterial nucleolus for cold adaptation

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis1,2. Bacteria are generally thought to lack an equivalent compartment. Here we discover a nucleolus-like condensate in Escher...

M. Gut, K. Dörner, Sebastian Abegg et al. · 0 citations
Open access Aug 2026

PAIP1 couples mRNA export to cytoplasmic mRNP remodeling and poly(A) homeostasis

This work identifies PAIP1 as a metazoan cofactor of the mRNA export ATPase DDX19, and identifies an export-coupled mRNP maturation pathway linking PABP exchange to downstream mRNA metabolism.

D. Overwijn, K. Dörner, Caroline de Almeida et al. · 0 citations

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