Tumor-Immune Microenvironment of Early-Onset Colorectal Cancer: Implications for Immune-Based Prevention and Therapy.
This review synthesizes current evidence on the TiME of EOCRC and contrast it with that of conventional LOCRC, and explores how these insights inform immune-based prevention and immunotherapy strategies, including checkpoint blockade and rational combinations in the predominant microsatellite-stable EOCRC population.