Open access
Aug 2026
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer’s disease pathology and microglial responses in chimeric mice
A chimeric model of AD is generated by transplanting isogenic APOE3 or APOE4 human induced pluripotent stem cell-derived astrocyte progenitors into neonatal AD mice and highlighting a role for human astrocytes and APOE-dependent astrocyte functions in modulating AD-related pathology.
Joan Cruz-Sesé, Marta Mirón-Alcala, Maria Alfonso-Triguero et al.
· Cell Reports · 0 citations