Open access
Sep 2026
Microglial dectin-1/Clec7a in an alzheimer’s disease model: a double-edged sword across the lifespan
Microglial dectin-1 exerts age-dependent effects: beneficial for amyloid pathology in mid-life but detrimental for cognition and anxiety-related behavior in later life, highlighting the need to consider age, the cell types expressing dectin-1, and dectin-1-activating ligands.
Wen-Tin Xi, R. Rodriguiz, William C. Wetsel et al.
· Frontiers in Immunology · 0 citations