Author

Marcus R. Kelly

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Open access Sep 2026

Identifying multigenic modules under selection in the tumor genome

Abstract Motivation Genomic alterations in cancer arise from selective pressures acting on hallmark molecular modules, layered over a background of random mutagenic events. Methods to detect selection at the level of modules, as opposed to genes or nucleotides, are relatively underdeveloped. Results Here we present Can...

Marcus R. Kelly, Burçak Otlu, Roded Sharan et al. · Bioinformatics · 0 citations

Open access Aug 2026

Discovery and Targeting of a Cryptic Human Proteome

First-in-class therapeutics require first-in-class biology. Yet despite decades of genomic and proteomic cataloging, vast regions of the human transcriptome remain dark and their encoded proteins invisible. Here we present RyboCypher™, an integrated RNA-sequencing and AI-assisted proteogenomics platform that systematic...

J. Chick, Ashley R Woodfin, Jessica Weir et al. · bioRxiv · 0 citations