Open access
Oct 2026
5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens core
The serotonin 2A receptor (5-HT 2A ) is a G q/11 -coupled receptor implicated in reward processing, neuropsychiatric disorders, and the actions of serotonergic psychedelics. Although 5-HT 2A activation has been shown to engage endocannabinoid (eCB) signaling in several brain regions, its role in inhibitory syna...
Camila Estay-Olmos, Koyam Morales-Weil, Juan Ahumada et al.
· Frontiers in Pharmacology · 0 citations