Myocardial infarction is a leading cause of death and disability worldwide. Ischemic injury leads to irreversible loss of cardiomyocytes, the contractile cells of the heart, and formation of a fibrotic scar. After infarction, macrophages massively infiltrate the heart and orchestrate the tissue repair process by removi...
Giuseppe Rizzo, Marie Piollet, T. Krammer et al.· bioRxiv· 0 citations
Pulmonary tuberculosis (TB), caused by lung infection with Mycobacterium tuberculosis (Mtb), often manifests both alveolar pneumonia and aggregation of immune cells containing Mtb, termed granulomas, within the same lung. Here, we integrate spatial transcriptomics, single-cell RNA sequencing, high-resolution imaging, a...
Rosane M. B. Teles, Chaouki Benabdessalem, Jonathan Perrie et al.· Nature Communications· 0 citations
An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.
Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al.· Nature· 2 citations
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