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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Marcela V. Maus

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2 papers indexed here

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Aug 2026

T-cell immunosenescence limits CD19 CAR T-cell function in chronic lymphocytic leukemia.

CD19-directed CAR T-cells (CTL019) can produce durable remissions in chronic lymphocytic leukemia (CLL), but therapeutic success depends on whether autologous T-cells expand, persist, and retain cytotoxic function after manufacturing. Failure of CLL T-cells is often attributed to exhaustion, although many dysfunctional...

Julia Han Noll, Devin Dersh, Jiang-Yuan Li et al. · 0 citations
Sep 2026

Rational Engineering of Notch1 Signaling to Boost the Proliferation of CD19-BBζ CAR-T.

A critical role of Notch1 in CAR-T effector function is demonstrated and a novel strategy to augment endogenous Notch1 activity by leveraging native gene regulation is provided to augment endogenous Notch1 activity by leveraging native gene regulation.

M. Phillips, F. Birocchi, Felix Korell et al. · 0 citations

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