Author

Marcel Leist

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Open access Sep 2026

Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study.

This work explores the applicability of new approach methodologies (NAMs) using a read-across approach to predict systemic toxicity with liver as the critical target organ, and derive a point of departurefor the target compound (TC) difenoconazole. Eight conazoles were used as source compounds (SCs), alongside metaboli...

Barira Islam, Jenny Irwan, L. Wijaya et al. · Archives of Toxicology · 0 citations

Open access Oct 2026

Saccharopine and α-Aminoadipic Acid as Potential Biomarkers for Mitochondrial Stress in Neurons

Redox stress and subsequent metabolic reprogramming are well-known consequences of neuronal exposure to mitochondrial toxicants. Here, we investigated, using human neuronal cultures, how such changes are quantitatively reflected in the patterns of cellular and extracellular amino acids. We asked whether these alteratio...

Anna-Katharina Ückert, Anja Land, R. Pape et al. · Cells · 0 citations

use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

A conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process and the determination of a proper point-of-departure (PoD) for in vitro-in vivo extrapolation, allowing implementation in risk assessment procedures.

B. Blaauboer, K. Boekelheide, H. Clewell et al. · 0 citations