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Mao-Ting Shen

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Open access Sep 2026

A novel three-CpG signature for lung adenocarcinoma diagnosis: integrating multi-omics, machine learning, and clinical validation

Background Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide. The identification of non-invasive biomarkers for early detection is critical to improving patient outcomes. Integrative analysis of DNA methylation and gene expression represents a promising approach for identifying cancer-...

Qian-Ying Liu, Mao-Ting Shen, Li-Rui Yan et al. · 0 citations
Open access Aug 2026

Whole-exome sequencing reveals the genetic landscape and polygenic susceptibility in 1241 patients with clinically suspected hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a severe immunological disorder characterized by dysregulated immune activation. Pathogenic variants in HLH-causative genes serve as diagnostic criteria and guide treatment decisions. However, known genes do not fully explain the molecular basis of many cases, and the pol...

Yu-Huan Meng, Mao-Ting Shen, Shu-yi Guo et al. · 0 citations

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