Author

Mao-Lin Li

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Aug 2026

MitoGPS: A Mitochondrial DNA G-Quadruplex-Targeting Strategy for Tumor-Preferential Type I Photodynamic Therapy.

This work supports mtDNA G4-associated recognition as a strategy for improving the subcellular precision of PDT and provides a generalizable framework for developing mitochondria-directed phototherapies.

Yu-Hui Guo, Yao-Hui Shi, Pei-Min Huang et al. · Angewandte Chemie · 0 citations

Aug 2026

Lead Optimization of Quinoline-Coumarin KRAS mRNA G-Quadruplex Ligands: Discovery of Non-Quaternary Ammonium Analogs as Translation Inhibitors.

This study designed and synthesized a series of nonquaternary ammonium analogs to investigate whether this structural motif could be removed without compromising KRAS rG4-related activity and identified Q29 as a promising lead for further development of KRAS translation inhibitors.

Mao-Lin Li, Wen-Wei Li, Wen-Li Fu et al. · Journal of Medicinal Chemist... · 0 citations