Author

Manuela Petti

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Open access Sep 2026

Network based approach identifies miR-145-3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma.

In MTC cells, simultaneous inhibition of miR-145-3p together with its top co-expressed miRNAs increased proliferation and survival, and enhanced ERK phosphorylation, indicating MAPK pathway activation and a shift toward a more aggressive phenotype.

A. Citarella, Manuela Petti, Z. M. Besharat et al. · Journal of Pathology · 0 citations

Dataset Open access Jul 2026

VitaGraph: building a knowledge graph for biologically relevant learning tasks

VitaGraph is presented, a comprehensive multi-purpose biological knowledge graph built by integrating and refining multiple public datasets and enabling benchmarking of graph-based models and offering the opportunity to tackle tasks such as drug repurposing, PPI prediction, and side-effect prediction, among others.

Francesco Madeddu, Lucia Testa, Gianluca De Carlo et al. · Scientific Data · 0 citations