Current interest in the use of medicinal plants for the prevention and management of various diseases has increased significantly due to the need to identify effective, safe, and sustainable natural agents. Glechoma hederacea L., a perennial species belonging to the Lamiaceae family, has traditionally been used in European folk medicine for the treatment of respiratory, inflammatory, and digestive disorders. Modern research has highlighted a complex phytochemical profile dominated by phenolic acids, flavonoids, and volatile compounds that have been associated with a variety of biological activities. Experimental studies have reported antioxidant, antimicrobial, anti-inflammatory, and cytoprotective effects. The present review summarizes current data regarding the phytochemical composition and biological properties of Glechoma hederacea, with particular emphasis on its potential applications in oral hygiene products and complementary dental therapy.
Alicia-Denisa Bereteu-Costa, A. Pallag, Georgiana Ioana Potra Cicalău et al.· Plants· 0 citations
Environmental contamination by potentially toxic elements remains a public health concern in groundwater-dependent regions. This exploratory community-based cross-sectional study examined associations among a historical area-level arsenic screening classification, questionnaire-derived potential-exposure indicators, and self-reported symptom count in 275 adults from 37 standardized locality clusters in Satu Mare County, Romania. The arsenic Health Risk Index (HRI) screening classification was derived entirely from drinking-water measurements collected in a preceding regional study during 2022–2024; no water samples or exposure biomarkers were obtained in the present survey. The questionnaire-derived potential exposure index was calculated as the unweighted sum of seven binary indicators covering residential, drinking-water, occupational, dental, and dietary characteristics (theoretical range, 0–7; observed range, 0–6) and was analyzed continuously. Symptom count (theoretical range, 0–8) was analyzed primarily using negative binomial regression with locality-clustered standard errors and adjustment for age, sex, smoking, alcohol consumption, HRI classification, and self-reported comorbidity. Each one-point increase in the potential exposure index was associated with a modestly higher expected symptom count (adjusted incidence rate ratio = 1.106, 95% CI: 1.031–1.186; p = 0.005), whereas the area-level HRI classification was not statistically associated with symptom count (adjusted incidence rate ratio = 1.135, 95% CI: 0.829–1.554; p = 0.431). The association remained positive across alternative index specifications, although the drinking-water-focused estimate was smaller and less precise. These findings represent exploratory associations between reported potential-exposure characteristics and nonspecific self-reported symptoms; they do not establish individual arsenic exposure, contaminant-specific effects, or causality.
Dana Claudia Filipoiu, D. Gîtea, Manuela Bianca Pașca et al.· Journal of Xenobiotics· 0 citations
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