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Author

Manuel Simões

3 papers indexed here

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Open access Sep 2026

Electrospun zein nanofibres incorporating NADES-phytochemical systems as sustainable antimicrobial wound dressings.

Bioactive wound dressings with antibacterial properties are attractive for infection control. Phytochemicals, products from plant secondary metabolism, like gallic acid (GA), ferulic acid (FA), coumaric acid (CouA) and perillyl alcohol (PA) show promising antimicrobial activity, but their poor water solubility and the...

Sofia Miguel Silva, A. Afonso, Manuel Simões et al. · 0 citations
Oct 2026

Structure-activity relationship and membrane-targeting mechanisms of shikimate-related metabolites against Gram-positive and Gram-negative bacteria.

AIMS The rise of antibiotic-resistant bacteria has intensified the search for novel antimicrobials. In this context, shikimic acid is a versatile scaffold widely used as a precursor to bioactive compounds and drugs. This study screened the antimicrobial activity and underlying mechanism of 18 shikimate-related metaboli...

A. Pereira, A. Afonso, P. Silva et al. · 0 citations
Open access Sep 2026

Enhancing antimicrobial photodynamic inactivation through natural alkaloid-antiseptic synergy against methicillin-resistant Staphylococcus aureus.

HA and PM substantially enhanced the antibacterial performance of OCT and PHMB under photodynamic activation, enabling complete S. aureus inactivation, and highlight PS-antiseptic combinations as a promising non-antibiotic strategy for chronic wound management while reducing the required PS and antiseptic concentration...

Lília S. Teixeira, Sónia Fraga, Manuel Simões et al. · 0 citations

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