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Author

Manuel F. Navedo

2 papers indexed here

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Open access Sep 2026

Blood Pressure Tunes the Functional Coupling of Cerebrovascular CaV1.2 Channels.

BACKGROUND The myogenic response is the key autoregulatory mechanism that sets cerebral blood flow, and its mechanistic foundation is intimately tied to depolarization and the voltage gating of L-type Ca2+ channels (CaV1.2). Although critical, this study argues for an additional mechanism. We hypothesize that increased...

G. Mironova, Miguel A. S. Martín-Aragón Baudel, C. Lambride et al. · 0 citations
Open access Sep 2026

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface.

Mechanosensation is fundamentally viewed as a plasma membrane phenomenon. We challenge this paradigm by introducing intracellular mechanosensation in intestinal smooth muscle. We hypothesized that a distinct, organelle-based signalling axis exists to amplify mechanotransduction from the inside out. To test this we inve...

Geoanna M. Bautista, Declan Manning, Emily C. Lieu et al. · 0 citations

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