Sep 2026
Suppression of Costimulation Blockade-Resistant Memory CD8+ T cell-Mediated Rejection by TIGIT Agonism.
BACKGROUND Costimulation blockade-based immunosuppression with belatacept confers improved renal function compared with calcineurin inhibitors, but comes at a cost of increased incidence and severity of early acute rejection. Strategies to limit costimulation blockade-resistant immune cells are needed. We have previous...
Christina R. Hartigan, Catherine D. Martinez, M. Wagener et al.
· Transplantation · 0 citations