Man-Yu Han

Decoding the IL-12 Cytokine Family in Sjögren's Disease: Pathogenic Networks and Translational Implications.

BACKGROUND Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by exocrine-gland dysfunction and heterogeneous extraglandular manifestations. The IL-12 cytokine family, comprising IL-12, IL-23, IL-27, and IL-35, may contribute to SjD through interconnected immune and JAK-STAT signaling pathways. O...