Malvi Surti

Machine Learning-Guided Discovery of NEU1-Targeting Natural Compounds with Relevance to Mitochondrial Dysfunction-Linked, Fatigue-Associated Neurodegeneration in Alzheimer’s Disease

Alzheimer’s disease (AD), the most common form of dementia, is characterized not only by amyloid-beta (Aβ) accumulation and tau pathology but also by mitochondrial dysfunction, reduced energy metabolism, oxidative stress, and fatigue-associated neuronal damage. Neuraminidase-1 (NEU1), a lysosomal sialidase involved i...