Makoto Nishiyama

Structures and functions of enzymes involved in primary and secondary metabolite biosynthesis mediated by amino-group carrier protein.

Thermus thermophilus, an extremely thermophilic bacterium, synthesizes lysine through a novel type of 2-aminoadipate (AAA) pathway. The pathway starts from the synthesis of homocitrate using 2-oxoglutarate and acetyl-CoA. Homocitrate is converted to 2-oxoadipate by sequential reactions similar to the corresponding reac...