Open access
Oct 2026
Spatial Atlas of Small Cell Lung Carcinoma Reveals Intratumoral Tumor‐State Heterogeneity and an MMP12 + Macrophage Niche
ABSTRACT Small‐cell lung carcinoma (SCLC) is a highly aggressive tumor with a dismal prognosis among lung cancers. Treatment is failing because of primary or rapidly developing secondary resistance. Recent molecular studies have suggested four SCLC subtypes with unique therapeutic vulnerabilities—ASCL1, NEUROD1, POU2F3...
Naozane Nomura, N. Jimbo, Takaaki Nakanishi et al.
· Cancer Science · 0 citations