Author

Mai-Lin Gan

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Open access Oct 2026

An m7G tRNA-derived fragment mediated thermogenic activation of brown adipose tissue through post-transcriptional repression of Uqcr10.

This study indicates that tRF-Lys-CTT functions as a post-transcriptional regulator of metabolism that suppresses thermogenesis, and provides new insights into the regulatory relationship among the METTL1/m7G/tRF axis and thermogenic control.

Xue-Rui Zhao, Mai-Lin Gan, Xing-Yu Wang et al. · Journal of Biological Chemis... · 0 citations

Open access Sep 2026

Integrative Multi-Omics Analysis Reveals Germplasm Advantages and Candidate Mechanisms Underlying High Intramuscular Fat Deposition in Wuhuang Pigs

Intramuscular fat (IMF) content is a key indicator of pork eating quality. Wuhuang pigs, a fat-type local breed of Sichuan, exhibit high IMF, but the underlying mechanisms remain unclear. Here, Wuhuang and foreign-breed pigs were compared by integrated phenotypic, transcriptomic, metabolomic and 16S rRNA analyses. Crud...

Xing-Yu Wang, Yan Zhu, Lin-Yuan Shen et al. · Foods · 0 citations

Review Open access Aug 2026

RNA Chemical Modifications in Mammalian Skeletal Muscle Development, Homeostasis, and Disease: Regulatory Mechanisms and Chemical Biology Perspectives

This article systematically reviews the progress in the study of RNA modification in regulating the fate of skeletal muscle, focusing on the dynamic regulatory mechanisms and pathophysiological significance of N6-methyladenosine (m6A) modification in muscle differentiation, regeneration, and atrophy.

Du-Jun Chen, Mai-Lin Gan, Yu-Hang Lei et al. · Molecules · 1 citation