Author

Maggie Horst

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Open access Sep 2026

De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles.

Fluorescent imaging in live cells is a cornerstone of life sciences. While natural fluorescent proteins have been engineered to enhance individual features, no existing tag combines ideal properties into a single system: high brightness, reversible binding, compact size, and stability across diverse conditions. Here, w...

Yu-Da Chen, Klaus Yserentant, Kibeom Hong et al. · Cell · 0 citations

Open access Aug 2026

De novo design of a protein fold for small-molecule binding through aromatic π stacking

The de novo design of proteins that bind chemically complex small molecules has broad chemical and biological implications, but strategies typically rely on a small set of protein scaffolds and require extensive experimental screening. Here, we computationally designed proteins around a minimal aromatic π-stacking moti...

S. Ouchida, Maggie Horst, Xuxu Gou et al. · bioRxiv · 0 citations