Rspo1 dependent WNT signaling safeguards ovarian development by suppressing androgen signaling
Embryonic ovarian development requires high levels of WNT/ß-catenin signaling yet the molecular basis of this requirement remains unclear. Mutations in the WNT potentiator RSPO1 impair ovarian development in both mouse and human, leading to gonadal masculinization in XX individuals. Here, we show that RSPO1 acts within...