Open access
Oct 2026
A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors
The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (MTase) NSP14 inhibitor whose translational deve...
Cindy Meyer, Aitor Garzia, J. R. Merritt et al.
· Journal of Medicinal Chemist... · 0 citations