Functional evidence is provided that defective mitochondrial function in these conditions is, at least in part, reversible with targeted CoQ10 therapy, underscoring the importance of early genetic diagnosis and timely initiation of CoQ10 supplementation.
Achanya S. Jayan, Priya Nataraj, Arun Kumar Gangadharan et al.· Metabolic brain disease· 0 citations
OBJECTIVE
Parkinson's disease (PD) lacks reliable, minimally invasive biomarkers for diagnosis. This study aimed to identify and validate PD-specific plasma extracellular vesicle (EV)-associated proteins.
METHODS
Plasma EVs were isolated by ultracentrifugation and characterized. Proteomic profiling of total plasma EV...
Deepthy Chandran, Unnati Agrawal, D. Damayanthi et al.· Annals of Neurology· 0 citations
The EV miRNAs, specifically, hsa-let-7e-5p, hsa-miR-19b-3p, hsa-miR-24-3p, and hsa-miR-331-5p are promising candidates for PD diagnosis as they are associated with regulatory pathways involved in PD pathogenesis.
