Open access
Sep 2026
An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism
ATTR amyloidosis is caused by transthyretin (TTR) amyloid deposition, yet the sequence-encoded events linking TTR misfolding to fibril nucleation and structural polymorphism remain incompletely defined. Here, we exploit the modular organization of patient-derived TTR fibrils to investigate two components of the patholo...
Laxmikant Gadhe, B. Nguyen, María del Carmen Fernández-Ramírez et al.
· bioRxiv · 0 citations