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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Maciej Cieśla

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Open access Jun 2026

Dual promoter architecture of NFE2L2 underlies isoform-specific translational control of NRF2

Transcription factor NRF2 (encoded by the NFE2L2 gene) is a central signalling hub that coordinates antioxidant, detoxification, anti-inflammatory and metabolic programmes to maintain cellular homeostasis, with broad relevance to degenerative diseases, chronic inflammation and cancer. NFE2L2 is transcribed from two pro...

A. Sznarkowska, Zuzanna Urban-Wójciuk, Alicja Dziadosz-Brzezińska et al. · 0 citations
Review Sep 2026

The splicing axis of aging: mechanisms and therapeutic opportunities.

Aging is characterized by progressive loss of molecular fidelity that compromises stem-cell function and tissue homeostasis. Aging transcriptomes show widespread disruption of RNA processing, including increased intron retention, cryptic splice-site usage, and altered RNA quality control. These changes arise from somat...

Sada Raza, Ankita Kumari, Maciej Cieśla · 0 citations
Review Open access Aug 2026

Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection

This work shows that MDA5 binds aberrant host RNA induced during viral infection, and proposes that MDA5 surveys RNA processing fidelity and can detect infections by sensing perturbations of post-transcriptional events such as splicing.

Natália G. Sampaio, Tanja Davis, L. Gearing et al. · 1 citation

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