Author

M. Wöhr

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Open access Sep 2026

Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.

Serotonin (5-HT) regulates neurodevelopment and behavior. Whereas central 5-HT is synthesized by tryptophan hydroxylase (TPH)-2, the TPH1 isoform produces 5-HT peripherally. Although these systems are anatomically segregated, TPH1 gene polymorphisms have been linked to neuropsychiatric vulnerability, suggesting that pe...

Rogério C. R. Castro, N. Alenina, E. E. Natasha et al. · Brain, behavior, and immunit... · 0 citations

Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

It is demonstrated that 5-HT depletion disrupts behavioral neurodevelopmental trajectories via interactions between genetic, environmental, and ecological factors, highlighting the importance of accounting for sex, environment, and developmental timing in translational research.

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations

Open access Aug 2026

GluD1 Modulates GluN2B-containing NMDAR Function and Plasticity at Subicular Synapses

It is demonstrated that GluD1 is indispensable for preserving GluN2B-containing NMDAR function, synaptic plasticity, and memory, providing molecular insight into how GluD1 regulates NMDAR subtypes implicated in synaptic dysfunction in neuropsychiatric disorders.

Eric Purisic, Darielle Lewis-Sanders, Marian Zhong et al. · bioRxiv · 0 citations