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Author

M. Waxham

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Open access Sep 2026

PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis

Summary Autophagy is a homeostatic mechanism for recycling cellular constituents. In primary murine neurons, autophagosome biogenesis declines during aging. Importantly, this decline can be restored by the ectopic expression of key autophagy component WIPI2B. The phosphorylation state of WIPI2B serine 395 is critical f...

Heather Tsong, M. Waxham, Andrea K. H. Stavoe · 1 citation
Open access Sep 2026

CaMKII generates actin bundle morphology and mechanics distinct from canonical bivalent cross-linkers

Actin cross-linkers are essential modulators of the actin cytoskeleton, enabling structural diversity and dynamic remodeling. Among them, calcium/calmodulin-dependent protein kinase II (CaMKII) is unique in serving a dual role as a kinase and as a multivalent structural binder of actin in dendritic spines, where it pla...

Sofía Vargas-Hernández, Carlos Bueno, Madiha Syeda et al. · 0 citations

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