M. Vidailhet

Striatal network dysfunction underlying speech impairment in early Parkinson’s disease

The pathophysiology underlying Parkinson’s disease (PD) speech impairments and its potential sex differences remain unclear. We investigated sex-specific alterations in speech and striato-cortical networks in 104 patients with early PD (68M/36F), and 44 healthy controls (23M/21F), using quantitative speech markers and...

Interrater reliability of Tremor Characterization

Saccadic network dysfunction underlies eye-movement variability in early Parkinson’s disease

Parkinson’s disease is a neurodegenerative disorder characterized by altered subcortical-cortical connectivity, leading to motor and cognitive deficits. Saccadic eye movement abnormalities are among the earliest and most persistent markers of the disease, serving as sensitive indicators of disrupted oculomotor and cogn...

Fifteen-Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism.

BACKGROUND Bilateral pallidal deep brain stimulation (GPi-DBS) is effective for dystonia. Long-term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. OBJECTIVES To assess 15-year dystonia outcomes and characterize parkinsonism after bilateral GPi-DBS. METHODS...

Deep brain stimulation for the treatment of patients with dystonia: advances towards network-based personalised care.

Advances in non-invasive neurophysiological techniques, intraoperative recordings, and connectome-based neuroimaging have provided new insights into how DBS modulates these pathological networks.