Summary Stem-cell-based human embryo models offer an ethically tractable platform for studying early human development. This study employs somitoids, three-dimensional models of human somitogenesis, to investigate how transcriptional programs and culture conditions influence somite formation and segmentation. We show t...
Maria Teresa Alejo-Vinogradova, Y. E. Strøm, L. Lamers et al.· Stem Cell Reports· 0 citations
SetDB1 is best known for catalyzing H3K9me3, but it also influences H3K27me3 deposition, CTCF-binding, and DNA methylation (DNAme). Given the interplay between DNAme and the other epigenetic features, we profiled DNAme following Setdb1 knockout (KO) in ground-state and serum-grown mouse embryonic stem cells (ESCs) to i...
Nick G. P. Bovee, E. Habibi, Zi-Cong Liu et al.· Stem Cell Reports· 0 citations
Epigenetic regulation is essential for development and adaptation across eukaryotes. However, a comprehensive overview of the molecular framework of chromatin-mediated regulation, particularly in non-model organisms, is lacking. Here, we present a systematic proteomic characterization of the chromatin domains in P. fal...
Gala Ramón-Zamorano, Sheila Mainye, Jessica Kimmel et al.· Cell Host and Microbe· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
