BackgroundFrailty is characterized by declining homeostatic reserves and increased vulnerability to stressors, and has been associated with cognitive decline and dementia.ObjectiveTo examine the relationship between frailty, Alzheimer's disease (AD) biomarkers, and cognitive performance in individuals with mild cogniti...
Manuela Pintus, M. Valletta, L. Sacchi et al.· Journal of Alzheimer's Disea...· 0 citations
Overall, current evidence on p-tau217 is derived mainly from selected populations and may not fully reflect real-world clinical diversity, so future studies should prioritize more representative cohorts and standardized reporting of key variables will be essential to strengthen its adoption in clinical practice.
M. T. Blasi, Simona Buscarnera, M. Salzillo et al.· Ageing Research Reviews· 0 citations
ABSTRACT Background Gait speed (GS) has been suggested as a predictor of incident dementia in old age. However, the mechanisms underlying this body–mind connection remain unclear, and it is still unknown whether trajectories of GS decline differ according to levels of blood biomarkers related to Alzheimer's disease (ad...
Javier Leal-Martín, G. Grande, Caterina Gregorio et al.· Journal of Cachexia, Sarcope...· 0 citations
Easily accessible blood-based biomarkers of AD may be linked to subsequent faster cognitive decline in the general older population, with patterns suggesting some heterogeneity across biomarkers and that individual characteristics may influence clinical interpretation.
E. J. Laukka, I. Ekström, Martina Valletta et al.· JAMA Network Open· 0 citations
In cognitively unimpaired older adults, elevated blood p-tau217 was linked to faster shrinkage in AD-specific brain regions, whereas NfL and GFAP were associated with more widespread atrophy, with NfL also associated with accelerated WMH accumulation.
Martina Valletta, D. L. Vetrano, E. J. Laukka et al.· Annals of Neurology· 0 citations
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