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Open access Sep 2026

A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia

Microglial activation in response to lipopolysaccharide (LPS) requires Toll-like receptor 4 (TLR4) redistribution into cholesterol- and sphingolipid-rich membrane domains, yet the lipid determinants of this process remain unclear. Here, we identify cholesterol accessibility as a key driver of TLR4-dependent microglial...

C. Antón-Barros, Beatriz Villarejo-Zori, Sara Carmona-Lorenzo et al. · 0 citations

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