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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

M. Tong

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Review Open access Oct 2026

Covalent Recruitment of E3 Ligases: A New Path for Rational Design of Protein Degraders.

The covalent recruitment of E3 ubiquitin ligases is a rapidly advancing strategy in targeted protein degradation (TPD). While traditional non-covalent PROTACs and molecular glues operate through transient binding equilibria that can limit catalytic efficiency, covalent degraders form irreversible bonds with E3 ligases,...

Zi-Yan Yu, Jian-Qiang Zhang, M. Tong et al. · 0 citations
Open access Aug 2026

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

A PHB2–ACSL3 lipid‐metabolic axis that drives ferroptosis escape is defined and Mavorixafor repurposing is identified as an immediately translatable strategy to overcome cisplatin resistance in treatment‐refractory GC.

Liang Xu, Wanying Xiang, Xinyue Wang et al. · 0 citations

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